MOTS-C 20mg (Mitochondrial-Derived Peptide) – High-Purity Research Grade

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Product Overview: What is MOTS-C 20mg?

MOTS-C (Mitochondrial Open Reading Frame of the 12S rRNA Type-C) is a novel, 16-amino-acid peptide encoded within the mitochondrial genome. Unlike nuclear-encoded peptides, MOTS-C belongs to a unique class of mitochondrial-derived peptides (MDPs) that act as metabolic signal transducers across cellular networks.

In mammalian research models, MOTS-C targets the skeletal muscle tissue and systemic metabolic pathways, playing a pivotal role in cellular energy homeostasis, metabolic regulation, and stress response mechanisms.

Key Specifications

• Compound Name: MOTS-C (Mitochondrial Open Reading Frame of the 12S rRNA Type-C)

• Sequence: Met-Arg-Trp-Gln-Glu-Met-Gly-Tyr-Ile-Phe-Tyr-Pro-Arg-Lys-Leu-Arg

• Molecular Formula: C101H152N28O22S2

• Molecular Weight: 2174.6 g/mol

• CAS Number: 1627580-64-6

• Form: Lyophilized (freeze-dried) powder

• Purity: $\ge$ 99% (HPLC validated)

• Storage Conditions: Store at -20°C (-4°F) for long-term stability; protect from light and moisture.

The Science of MOTS-C: Primary Research Applications

Researchers across the United States actively investigate MOTS-C for its unique cellular signaling properties and metabolic functions. Below are the key areas of active scientific study:

1. Metabolic Regulation & Glucose Homeostasis

MOTS-C functions as a metabolic hormone that influences systemic insulin sensitivity and energy balance. Scientific studies suggest that MOTS-C translocates to the cell nucleus during metabolic stress, binding to specific response elements to regulate nuclear gene expression.

• AMPK Activation: MOTS-C stimulates AMP-activated protein kinase (AMPK), a central regulator of cellular energy balance.

• Glucose Uptake: Research indicates that MOTS-C promotes glucose transport into skeletal muscle cells independently of classical insulin pathways.

2. Mitochondrial Dynamics & Energy Balance

Mitochondria are the primary powerhouses of eukaryotic cells. MOTS-C plays an integral role in maintaining mitochondrial health and cellular respiration rates during exercise-induced or metabolic stress.

• Folate Cycle Regulation: MOTS-C interacts directly with the folate cycle and methionine metabolism, influencing cellular methylation pathways.

• Metabolic Flexibility: Investigational models demonstrate enhanced capacity to switch between carbohydrate and lipid oxidation under varying nutrient conditions.

3. Physical Performance & Muscle Physiology

In preclinical studies, administration of MOTS-C in rodent models demonstrated significant improvements in exercise capacity, physical endurance, and resistance to metabolic stress associated with aging or high-fat diets.

• Muscle Fiber Adaptation: Supports metabolic signaling pathways that mirror the cellular adaptations induced by endurance exercise.

• Anti-Fatigue Signaling: Aids in downregulating oxidative stress markers in active tissue preparations.

Why Buy MOTS-C 20mg from Summit Biotech?

When procuring research peptides in the United States, batch purity, analytical verification, and reliable delivery are essential. summit-biotechusa.com stands out as the premier official store for laboratory-grade research compounds.

Feature	Summit Biotech (summit-biotechusa.com)	Industry Standards
Purity Level	$\ge 99\%$ HPLC Certified	Often 90–95% Unverified
Testing Protocol	Mass Spectrometry (MS) & High-Performance Liquid Chromatography (HPLC)	Minimal or Inhouse-Only Verification
Formulation	Lyophilized powder in vacuum-sealed glass vials	Inconsistent moisture control
Shipping	Fast, climate-controlled USA fulfillment	Prolonged international transit times

Uncompromised Quality Control

Every batch of MOTS-C 20mg available at summit-biotechusa.com undergoes rigorous analytical testing:

1. High-Performance Liquid Chromatography (HPLC): Guarantees peptide purity exceeds 99%, eliminating unwanted synthesis sequence errors or truncations.

2. Mass Spectrometry (MS): Confirms exact molecular mass and sequence alignment.

3. Sterility & Endotoxin Verification: Ensures freedom from bacterial contamination and residual solvents.

Reconstitution & Handling Guidelines (For Laboratory Use)

To maintain maximum chemical integrity and stability during experimental workflows, adhere to standard peptide handling procedures:

1. Equilibration: Allow the lyophilized vial of MOTS-C 20mg to reach room temperature before reconstitution to prevent condensation inside the container.

2. Reconstitution: Slowly introduce Bacteriostatic Water or Sterile Water for Injection down the glass side wall of the vial. Do not spray liquid directly onto the lyophilized cake.

3. Dissolution: Gently swirl the vial in a circular motion until completely dissolved. Do not shake violently, as vigorous agitation can disrupt delicate secondary peptide bonds.

4. Storage Post-Reconstitution: Reconstituted MOTS-C solution should be stored at 2°C to 8°C (36°F to 46°F) and used within 28 days to maintain optimal biological activity.

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